Drugmetabolism相关论文
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and ho
Acetaminophen(APAP)is a widely used analgesic and antipyretic drug,which is safe at ther-apeutic doses but can cause sev......
临床上经常遇到结核病（TB）合并丙型肝炎病毒（HCV）感染者需要同时治疗。当抗HCV和抗TB药物联用时需要考虑药物-药物之间的相互作用（DDIs）......
The 2020 Nobel Prize in Chemistry recognized CRISPR-Cas9,a super-selective and precise gene editing tool.CRISPR-Cas9 has......
Relationship between Permeability Glycoprotein(P-gp)Expression and methylene blue metabolism in Angu
The aim of this study was to analyze the influence of permeability glycoprotein(P-gp)gene expression on methylene blue(M......
Micropatterned cell coculture on electrospun fibrous scaffolds for as a potential in vitro model for
The stringent safety and efficacy criteria,along with the high cost of bringing new drug compounds into the market,are l......
A new accurately and reliably method to measure the concentration of isoniazid concentration in rabb
Isoniazid(INH)is an effective agent for TB therapy that rapidly permeates the bacterial cell membrane via passive diffus......
Objective: To study the effects of gatifloxacin on hepatic microsome cytochrornes P450.Methods: The male Wistar rats wer......
Aim: To investigate the stereoselective metabolism of phencynonate.Methods: Phencynonate enantiomers were isocratically ......
Generation and characterization of a novel CYP3A1/2 double knockout rat model using CRISPR-Cas9 syst
OBJECTIVE Cytochrome P450 (CYP) 3A accounts for nearly 30% of total CYP enzymes in human liver and participates in the m......
Microdosing cocktail study on the determination and pharmacokinetics of six hepatic cytochrome probe
OBJECTIVE To describe a highly sensitive LC-ESI MSn method that was developed to simultaneously detect six CYP isoform-s......
ESTABLISHMENT OF CRYOPRESERVATION AND RETRIEVE SYSTEM OPTIMIZED FOR HUMAN EMBRYONIC STEM CELLS-DERIV
The liver is a multifunctional organ and,liver diseases,such as hepatitis,cirrhosis,liver cancer,create severe health-th......
PURPOSE: To further elucidate the correlation of resveratrol sensitivities with biotransformation activities of huma......
Cytochrome P450(P450)enzymes are the major catalysts involved in the metabolism of drugs,steroids,chemical carcinoge......
A CYP450 Oligonucleotide Microarray for Detecting Genetic Variations of CYP2C9,CYP2C19,CYP2D6 and CY
The cytochrome P450 enzymes play a critical role in the metabolism of many commonly prescribed drugs.Among them,the ......
Imitation of drug metabolism in cell co-culture microcapsule model using a microfluidic chip platfor
In this work, a multi-functional analysis platform by coupling a microfluidic chip to a mass spectrometry (MS) detector ......
尿苷二磷酸葡萄糖醛酸转移酶(LGT)是药物Ⅱ相代谢中至关重要的酶,而尿苷二磷酸葡萄糖醛酸转移酶2B7(LGT2B7)基因多态性对LGT的活性......
综述药物代谢模型研究现状。检索数据库相关文献，分析、汇总。药物代谢模型多种，机制多样。各模型均有其自身的优缺点，研究者应根据研......
Rational prescription of drugs within similar therapeutic or structural class for gastrointestinal d
AIM: To review and summarize drug metabolism and its related interactions in prescribing drugs within the similar therap......
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新药研究的过程一般可分为药物设计和新药开发两个阶段。药物设计包括:(1)针对某一特定治疗靶点设计先导化合物,(2)根据先导化合物......
Rational prescription of drugs within similar therapeutic or structural class for gastrointestinal d
瞄准：在在类似的治疗学或结构的班以内开药让胃肠的疾病处理以便在临床的实践支持药的合理使用考察并且总结药新陈代谢和它的相关相......
